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Visipaque is an isosmolar contrast agent developed to further improve the toxicity profile of contrast agents, suitable for patients considered at high risk for cardiovascular or renal insult. Appropriate selection of contrast media for necessary diagnostic or interventional procedure imaging in high-risk patients should be considered to help mitigate the risk of adverse events. Visipaque, an iodinated iso-osmolar, isotonic contrast agent indicated for multiple intra-arterial and intravenous procedures, was prepared with this in mind. Interventional, structural, or endovascular procedures (e.g., TAVI, CTO, PCI) may need to use higher volumes of iodinated CM. Reducing the frequency of adverse reactions has therefore been a driving force in the development of these diagnostic agents since their initial introduction.
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